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KMID : 0369820160460020189
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Jorunal of Korean Pharmaceutical Sciences
2016 Volume.46 No. 2 p.189 ~ p.194
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Quantitative evaluation of mucoadhesive polymers to compare the mucoadhesion
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Lee Cho-A
Kim Bo-Sik
Cho Cheong-Weon
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Abstract
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Mucoadhesive drug delivery systems has received noticeable attentions in the pharmaceutical field, resulted in the adhesion of the drug to the tissue for a prolonged period of time. Three kinds of methods such as tensile strength test, mucin particle method and rheology were used to compare the quantitative mucoadhesion of mucoadhesive polymers. Carbomer 940, chitosan, hydroxypropylcellulose, and sodium carboxymethylcellulose were used as mucoadhesive polymers. The mucoadhesion by tensile strength tester using rat stomach were in the order of hydroxypropylcellulose, sodium carboxymethylcellulose, chitosan and carbomer 940. Similarly, in mucin particle method, mucoadhesion was in order of hydroxypropylcellulose, sodium carboxymethylcellulose, chitosan and carbomer 940. The viscosity of mixture with mucin solution was in the order of hydroxypropylcellulose, sodium carboxymethylcellulose, carbomer 940 and chitosan. Still, there is little on the quantitative comparison of individual mucoadhesive polymer using the same mucoadhesion test. So, this study could be a basic data for the selection of mucoadhesive polymer.
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KEYWORD
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Mucoadhesion, Viscosity, Tensile strength, Zeta potential, Mucoadhesive polymers
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